Data · dataset · 2026
<p>Vaccine-induced immunity is activated after infection but is overcome by <i>F. tularensis</i> FSC200.</p>
Listed in ZivaHub
<p>(A) Mice immunized with a peptide vaccine (PepVac) or treated with the same adjuvant but without peptides (control) were subcutaneously infected with 53 CFU of <i>F. tularensis</i> FSC200, and the vaccine’s protective efficacy was evaluated.
Description
(B) Changes in body weight of mice during infection. The body weight of the mice on the day of infection (day 0) was used as the baseline, and the graph shows the percentage changes relative to that day.
Data from the four days prior to infection are also included. Values are presented as mean ± SD (one-sided). The data (days 1-5) were analyzed using a mixed-effects model with repeated measures, and multiple comparisons (PepVac versus control at individual time points) were corrected using Sidak’s post hoc test.
Read the rest (5 more)
An asterisk indicates a p-value < 0.05 for the interaction effect between time and treatment. (C) Survival curve for the vaccinated group (n = 8) and the control group of mice (n = 7). The dashed line indicates the median survival time for each group.
The data were analyzed using the Kaplan-Meier method with the log-rank test (ns for p ≥ 0.05).
Note
The unequal group sizes were due to the death of one mouse after administration of a booster dose as part of the immunization. The bacterial load in the spleen (D) and liver (E) of control and vaccinated mice (n = 5) was determined on day 4 postinfection. Data for individual mice and the corresponding mean values are shown.
A two-tailed t-test was used to assess statistical significance. Asterisks indicate p-values < 0.05. This experiment was performed once.</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.ppat.1014597.g007 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Biochemistry and cell biology · Cancer · Earth & Environmental Science · Immunology · Infectious diseases · Life Sciences · Medicine & Health · Microbiology
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34026937 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].anzsrc:field:320211 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:group:3101 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3107 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3204 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |