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Data · dataset · 2026

Association of CBC-derived systemic inflammation markers with first-episode peritonitis in peritoneal dialysis

Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.6084/m9.figshare.34046423.v1

<p>Peritoneal dialysis-associated peritonitis (PDAP) remains a major cause of technique failure in peritoneal dialysis (PD) patients.

Description

Novel complete blood count-derived inflammatory markers, including the systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and aggregate index of systemic inflammation (AISI), may provide accessible tools for early PDAP risk prediction.</p> <p>In this retrospective cohort study, 302 PD patients were stratified according to incident PDAP during follow-up.

Restricted cubic splines assessed nonlinear associations. Multivariable logistic regression evaluated independent associations with first-episode PDAP. Receiver operating characteristic curves assessed predictive performance.</p> <p>Baseline SII, SIRI, and AISI levels were significantly higher in the PDAP group than in the non-PDAP group (all <i>p</i> < 0.05).

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Higher Ln-SII (OR: 3.598; 95% CI: 2.204–5.872), Ln-SIRI (OR: 2.425; 95% CI: 1.584–3.714), and Ln-AISI (OR: 2.007; 95% CI: 1.403–2.871) were independently associated with increased PDAP risk (all <i>p</i> < 0.001). SII showed the highest discriminatory performance among the three markers, with an area under the curve of 0.689. A combined model incorporating SII, SIRI, and AISI achieved an AUC of 0.715.</p> <p>Higher SII, SIRI, and AISI levels were associated with an increased risk of first-episode PDAP.

A combined model demonstrates promising predictive accuracy.</p>

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Catalogue records · 1

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Inferred from text
Longitudinal study 65%
Provenance · 3 source records, 24 field assertions
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ZivaHuboai:figshare.com:article/3404642313 d agoJSON v1
Deakin Research Onlineoai:figshare.com:article/3404642313 d agoJSON v1
DMU Figshareoai:figshare.com:article/3404642313 d agoJSON v1
FieldAssertionExtractorEvidence
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