Omics · study · 2026
ScRNA-seq shows cardiac fibrosis and immune microenvironment activation in HCM mice
Listed in NCBI GEO
Hypertrophic cardiomyopathy (HCM), the most prevalent inherited cardiovascular disorder, confers elevated risks of stroke, progressive heart failure, and sudden cardiac death.
Description
Emerging evidence suggests that myocardial inflammation may contribute to the progression and complications of HCM. While colchicine has demonstrated therapeutic potential in reducing adverse cardiovascular events through its pleiotropic anti-inflammatory mechanisms in other cardiac conditions, its efficacy profile in HCM populations have not been investigated.
Our study offered preclinical evidence suggesting that colchicine may exhibit potential therapeutic efficacy in the treatment of HCM, thereby presenting a theoretical foundation for the application of colchicine in HCM.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299323 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299323 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1273908 ncbi.nlm.nih.gov/bioproject/PRJNA1273908 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cardiomyopathy 75% · Cardiovascular disease 65% · Heart 75% · Hypertrophic cardiomyopathy 75% · Single-cell RNA sequencing 65%
Provenance · 1 source records, 12 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE299323 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:cardiomyopathy | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:cardiovascular-disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[disease].local:disease:hypertrophic-cardiomyopathy | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:single-cell-rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |