Omics · study · 2026
Androgen receptor action in mouse granulosa cells in response to LH surge
Listed in NCBI GEO
Androgen receptor (AR) plays a prominent role in folliculogenesis and steroidogenesis, as well as ensuring the responsiveness to luteinising hormone (LH) surge in granulosa cells.
Description
The irregular elevation of canonical ligands for AR can induce polycystic ovary syndrome (PCOS) in animal models and is a clinical diagnostic indicator of PCOS in women. To determine the interrelationship between different steroid receptors in the ovarian context, we generated comprehensive AR cistrome datasets from granulosa cells of mice that were wildtype of knockout for progesterone receptor (PGRO) in response to in vivo LH stimulus.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE249nnn/GSE249984 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE249984 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1051553 ncbi.nlm.nih.gov/bioproject/PRJNA1051553 ↗
project · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE249984 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |