Data · dataset · 2026
Multifunctional peptide-mimetic material for controlled drug delivery to tumours
Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32633034.v1
Doxorubicin is a broad-spectrum anti-cancer drug that is dedicated to treating cancers such as neuroblastoma, breast cancer, and prostate cancer.
Description
Overcoming patient medication adherence concerns and complex drug dose protocols associated with present therapy, particularly a commitment to daily tablet usage, is critical to solving the global cancer issue. A practical and effective long-acting formulation to deliver drugs over a sustained period is required.
Through structural alteration, doxorubicin can be covalently linked to the peptoid-D-peptide sequence. The Michael addition process binds the doxorubicin-maleimide derivative to the peptoid-peptide. The development of nanofiber networks from the hydrogelator precursor is triggered by enzymatic transformation, which is a natural biological process.
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After a dephosphorylation event mediated by alkaline phosphatase, the precursor can self-assemble to create a red stable hydrogel. This hydrogel might keep drug release sustained, controlled and have a powerful anticancer impact. This study has the potential to serve as an injectable hydrogel for therapeutic applications as a new strategy for building a drug system of covalently bonding doxorubicin and peptoid-D-peptide.<br><br><i>Thesis embargoed until 31 December 2027.</i>
Links
Where it is published
- DOI doi.org/10.17034/32633034.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Nanofabrication, growth and self assembly · Nanofabrication, growth and self assembly · Nanofabrication, growth and self assembly · Nanofabrication, growth and self assembly
- Inferred from text
- Cancer 75%
Provenance · 4 source records, 14 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32633034 | 7 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32633034 | 7 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32633034 | 7 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/32633034 | 7 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:401805 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['self-assembly'] |
| concepts[field].anzsrc:field:401805 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['self-assembly'] |
| concepts[field].anzsrc:field:401805 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['self-assembly'] |
| concepts[field].anzsrc:field:401805 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['self-assembly'] |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |