Data · dataset · 2026
Image 1_Outbreak of porcine deltacoronavirus in pigs in central China, 2024.png
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.3389/fvets.2026.1934473.s001
<p>Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus responsible for acute diarrhea, vomiting, and dehydration in piglets, thereby posing a substantial threat to the global swine industry.
Description
In December 2024, a severe diarrheal disease outbreak occurred on an intensive pig farm in Hubei Province, located in central China. Here, we describe the isolation and genomic characterization of a novel PDCoV strain, designated SP2403-2, obtained from the intestinal contents of an affected piglet.
The virus was successfully propagated in cell culture and confirmed by immunofluorescence staining and transmission electron microscopy. The near-complete genome of SP2403-2, comprising 25,244 nucleotides, was sequenced. Comparative genomic analyses showed that SP2403-2 shares 97.0–99.2% nucleotide identity with reference PDCoV strains, with the highest similarity (99.2%) to the recently reported Chinese strain JSTZ2025.
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Phylogenetic analyses based on complete genome, ORF1ab, and S gene sequences demonstrated that SP2403-2 belongs to the Chinese lineage. Notably, alignment of the spike (S) protein of SP2403-2 with that of the vaccine strain CHN-HN-2014 revealed 25 amino acid substitutions. Structural mapping indicated that these mutations are predominantly located on the surface-exposed regions of critical domains within the S protein, potentially influencing antigenic epitopes and receptor-binding properties.
Our findings demonstrate that SP2403-2 represents a contemporary Chinese-lineage PDCoV strain carrying substantial S protein variation relative to the vaccine strain, underscoring the imperative for ongoing surveillance of emerging PDCoV variants and re-evaluation of current vaccine efficacy.</p>
Links
Where it is published
- DOI doi.org/10.3389/fvets.2026.1934473.s001 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Life Sciences · Life Sciences · Life Sciences · Veterinary anaesthesiology and intensive care · Veterinary anaesthesiology and intensive care · Veterinary anaesthesiology and intensive care
- Inferred from text
- Disease 75% · Image 75% · Microscopy 75%
Provenance · 3 source records, 17 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34032042 | 5 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34032042 | 5 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/34032042 | 5 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:300901 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Veterinary Anaesthesiology and Intensive Care'] |
| concepts[field].anzsrc:field:300901 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Veterinary Anaesthesiology and Intensive Care'] |
| concepts[field].anzsrc:field:300901 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Veterinary Anaesthesiology and Intensive Care'] |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[modality].local:modality:image | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:microscopy | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |