Data · dataset · 2025
Cell-specific protein expression in Alzheimer's disease prefrontal cortex
Listed in DataCite
Analyzing the proteomes of different brain cell types is fundamental for understanding the pathophysiology of Alzheimer's disease (AD).
Description
However, spatial analysis of these diverse and limited cell populations poses significant challenges. The GeoMx Digital Spatial Profiler (DSP) platform analyzed protein levels in the prefrontal cortex of AD and non-AD brains.
The platform interrogated 76 proteins and used immunofluorescence to distinguish between three cell types. Neprilysin, which promotes Aβ degradation, was significantly higher in AD neurons and microglia. LAMP2A level was higher in neurons of individuals with AD compared to a control group.
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Additionally, markers of neuroinflammation, such as CD11c, CD11b, and CD163, were also elevated in AD neurons. Our findings indicate that the DSP platform effectively facilitates cell-specific snapshots of the AD brain proteome.
Links
Where it is published
- Repository landing page datadryad.org/dataset/doi:10.5061/dryad.w6m905r12 ↗
landing page · from DataCite
- DOI doi.org/10.5061/dryad.w6m905r12 ↗
DOI / persistent id · from DataCite
Documentation and papers
- Creative Commons Zero v1.0 Universal creativecommons.org/publicdomain/zero/1.0/legalcode ↗
license · from DataCite
- IsCitedBy 10.1002/alz.70339 doi.org/10.1002/alz.70339 ↗
publication · from DataCite
Catalogue records · 2
- DataCite API api.datacite.org/dois/10.5061/dryad.w6m905r12 ↗
metadata API · from DataCite
- DataCite Commons commons.datacite.org/doi.org/10.5061/dryad.w6m905r12 ↗
catalogue entry · from DataCite
Topics
- Stated by source
- Basic medicine
- Inferred from text
- Disease 75% · Medical biochemistry and metabolomics 71%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DataCite | 10.5061/dryad.w6m905r12 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| byte_size | source · DataCite | connector:datacite@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · DataCite | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3205 | enrichment · DataCite | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].fos:basic-medicine | source · DataCite | connector:datacite@1.0.0 | |
| created_date | source · DataCite | connector:datacite@1.0.0 | |
| description | source · DataCite | connector:datacite@1.0.0 | /data/attributes/descriptions |
| license | source · DataCite | connector:datacite@1.0.0 | /data/attributes/rightsList |
| publication_date | source · DataCite | connector:datacite@1.0.0 | /data/attributes/dates |
| title | source · DataCite | connector:datacite@1.0.0 | /data/attributes/titles/0/title |
| version_label | source · DataCite | connector:datacite@1.0.0 |