Transcriptomic profile of patient derived glioblastoma stem cells from recurrent and newly diagnosed background

Thus we embark on a journey to investigate the transcriptomic profile of the patient derived GSCs from varied background. Considering the heterogeneity of the GSCs, it is of utmost important to study patient derived GSCs from varied bakground. Our pool of cells comprise of 2 recurrent patient derived GSCs and 2 newly diagnosed GSCs.

Our long term goal being to design and develop alternative nanotherpaeutic approaches to target the otherwise hard-to-target GSCs in the brain, we concentrated on using patient derived cells to closely recapitulate the tumor characteristics whiich would have been difficult if conventional cell lines were used. Thereby, a complete understanding of the genomic profile of the GSCs from varied patient background would help us figure out the best possible target site for therpeutics against GSCs and as a result delay/stop the tumor recurrence.