Data · study · 2026
Spatial mapping of senescent and disease-associated microglia in aged mouse brain white matter
Listed in NCBI GEO
The brain experiences age-associated molecular, structural, and functional changes that coincide with greater incidence of neurological disease.
Description
Senescent and inflammatory cells may contribute to the maladaptive remodeling and reprogramming of aging brain parenchyma and are potential mediators of age-dependent brain dysfunction. To detect senescent cells and their gene signatures with preserved spatial context, we employed GeoMx digital spatial profiling to analyze the distribution and biological heterogeneity of cell populations in young and aged mouse brain tissue slices.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333352 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333352 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1470732 ncbi.nlm.nih.gov/bioproject/PRJNA1470732 ↗
project · from NCBI GEO
- PubMed 42443609 pubmed.ncbi.nlm.nih.gov/42443609 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Mus musculus · Other
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE333352 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |