Omics · study · 2026
Transcriptome analysis of ureter tissues from wild-type and COL17 knockout mice.
Listed in NCBI GEO
Type XVII collagen (COL17A1) is well-characterized as a critical structural component of the epidermal basement membrane in the skin; however, its presence and function in the urinary tract remain poorly described.
Description
We discovered that COL17A1 is also expressed in the urothelium under urological condition. To elucidate the molecular mechanisms underlying early urothelial abnormalities caused by COL17A1 deficiency, we performed transcriptomic profiling (bulk RNA-seq) of ureter tissues from 2-week-old wild-type and Col17a1 knockout mice.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327077 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327077 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1449414 ncbi.nlm.nih.gov/bioproject/PRJNA1449414 ↗
project · from NCBI GEO
- PubMed 42045289 pubmed.ncbi.nlm.nih.gov/42045289 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE327077 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |