Omics · study · 2026
Lamins gate nuclear and chromatin structures for cardiomyocyte maturation genes. (CUT&RUN)
Listed in NCBI GEO
The nuclear lamina contains intermediate filaments, called lamins, which function to maintain nuclear integrity and organize the Lamina-Associated chromatin Domains (LADs).
Description
Despite near ubiquitous expression, lamins show cell-type-specific functions. In the heart, they support epicardial cell migration, cardiomyocyte nuclear integrity and maturation.
How these functions are integrated with different gene expression programs in these cells during heart development is unknown. We show that cardiomyocytes require lamin-A and -B1 for perinatal mouse survival. Importantly, lamin-B1 facilitates timely cardiomyocyte maturation by maintaining LADs and chromosome territories.
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By examining changes in cardiomyocyte gene expression and 3D genome organization upon lamin-B1 deletion, we show lamin-B1 maintains chromatin neighborhoods, which can in turn support transcription factors that regulate genes involved in cardiomyocyte structural maturation and gradual cessation of cell division. We propose a genomic logic by which the widely expressed lamins collaborate with transcription factors to specifically promote cardiomyocyte maturation and cell cycle exit during development.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330102 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330102 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1462735 ncbi.nlm.nih.gov/bioproject/PRJNA1462735 ↗
project · from NCBI GEO
- PubMed 42239077 pubmed.ncbi.nlm.nih.gov/42239077 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE330102 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |