Ketogenic diet exerted anti-seizure function related with alteration of lipid metabolism via pparγ signaling pathway

This study investigated the role of lipid metabolism modulation in the antiseizure effects of KD using a kainic acid (KA)-induced chronic epilepsy mouse model. Mice maintained on KD exhibited significantly reduced seizure frequency, duration, and severity, alongside decreased electrographic spike discharges and neuronal c-Fos expression compared to those on a chow diet (CD).

Transcriptomic analysis of temporal lobe tissue revealed several differentially expressed genes (DEGs) in KD-fed mice, with parts identified as lipid metabolism-related. Further analysis and experiments demonstrated key genes and pathways releated to the regulation of KD in lipid metabolism subsquently exerted anti-seizure effects.