Serial Reversal Learning in an Olfactory Discrimination Task in 3xTg-AD Mice

All mice learned the odour discriminations and reversals to a criterion of 85% correct, but the 3xTg-AD mice made fewer errors than the B6129F2/J mice in the odour discriminations and in the first six reversal learning tasks.

Many mice showed evidence of near errorless learning and on the reversal tasks, the 3xTg-AD mice showed more instances of near errorless learning than the B6129F2/J mice. There was no evidence of an age effect on odour discrimination, but there was a decrease in errorless reversal learning in aged B6129F2/J mice. In long-term memory tests there was an increase in number of errors made, but no genotype difference.