Data · dataset · 2026
Radionuclide therapy in advanced prostate cancer: from pain killer to disease modifier and beyond
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32634291.v1
The use of radionuclide therapy in prostate cancer has been a key focus of my research over the past 22 years.
Description
During that time, the use of radionuclide therapy in the treatment of metastatic disease has steadily increased. The initial wave of radionuclides used in prostate cancer were based on the classical prostate cancer phenotype of bone forming metastases which facilitated bone-targeted therapies such as Strontium-89 and Samarium-153 EDTMP.
These agents were effective at reducing pain however there was no disease modifying benefit. In the past 10 years (the time frame for the papers discussed in this critical analysis) my research has involved innovative clinical trials of combination of Rhenium-186 HEDP with chemotherapy, dosimetry studies of Rhenium-186, large trials developing Radium-223 as a life prolonging therapy, and a first ever trial of Radium-223 in metastatic castration sensitive prostate cancer.
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I believe that my work in radionuclide therapy in advanced prostate cancer has made an important contribution to keeping the field vibrant. The next wave of radionuclide therapies in prostate cancer are focused on a cell surface protein called Prostate Specific Membrane Antigen (PSMA) are already showing the potential for life-extension in advanced prostate cancer.<br><br><b><i>For copyright reasons this thesis is partially redacted.<br><br></i></b>
Links
Where it is published
- DOI doi.org/10.17034/32634291.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Cancer 75% · Disease 75% · Oncology and carcinogenesis 72%
Provenance · 3 source records, 16 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32634291 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32634291 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32634291 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3211 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |