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Table · dataset · 2026

Table 1_Triglyceride–glucose index and preserved ratio impaired spirometry in 89,809 individuals without self-reported overt clinical disease.docx

Listed in figshare and Loughborough Research Repository — shown once because both records carry DOI 10.3389/fmed.2026.1880988.s001

Introduction<p>While both preserved ratio impaired spirometry (PRISm) and triglyceride glucose index (TyG) are established risk factors for cardiometabolic diseases, the metabolic characteristics and prevalence of PRISm differ by ethnic group.

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However, this association has not been directly examined in Asian populations. Therefore, we aimed to investigate whether TyG is associated with PRISm in a large Korean population without self-reported overt clinical disease.</p>Methods<p>In this cross-sectional study, 89,809 adults (46,739 men; mean age: 38.5 years) with health examinations in 2019 were divided into quartiles according to their TyG.

Lung function phenotypes were evaluated using fixed cut-offs and lower limit of normal (LLN) criteria, with LLN defined as the 5th percentile of our study population. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for PRISm were estimated and compared to the lowest TyG quartile (reference) group.</p>Results<p>The mean TyG was 8.34 ± 0.57, and the prevalence of PRISm was 3.4%, showing a significant increase across TyG quartiles (p for trend < 0.001).

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Compared with the lowest quartile, the aORs (95% CI) for PRISm were 1.157 (1.030–1.299), 1.232 (1.085–1.398), and 1.368 (1.193–1.567) 1 across the increasing quartiles of TyG (p for trend < 0.001). A similar increasing trend was observed for the spirometric restrictive pattern (SRP) across TyG quartiles (p for trend < 0.001), whereas no significant trend was found for the obstructive pattern (OP) (p = 0.135). Results obtained using fixed cut-off criteria were highly consistent with those based on LLN criteria.</p>Discussion<p>In conclusion, higher TyG quartiles were associated with PRISm in middle-aged Koreans without self-reported overt clinical disease, suggesting the potential link between metabolic status and PRISm risk.

However, longitudinal studies are required to confirm these findings.</p>

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