Omics · study · 2026
Effect of Rv2282c, Rv1990c and Rv1985c overexpression on gene expression under ATc induction in Mycobacterium smegmatis [batch 1]
Listed in NCBI GEO
transcriptional regulation on DNA damage response is essential for persistence and mutagenesis of Mtb.
Description
We here report Rv2282c, Rv1990c and Rv1985c as regulators for DNA damage response system. Overexpression of Rv2282c, Rv1990c and Rv1985c greatly induce DNA replication and repair in a LexA-independent pathway, and inhibit cell division.
Rv2282c, Rv1990c and Rv1985c induce DNA damage response by affecting redox state in mycobacterium smegmatis.Complemention of tpx relieves the effect of Rv2282c, Rv1990c and Rv1985c. Taken together, our study provides a conceptual framework for understanding how mycobacteria orchestrate the complex DDR system through redox-based transcriptional regulation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327825 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327825 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1452867 ncbi.nlm.nih.gov/bioproject/PRJNA1452867 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Genetics 68%
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE327825 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (68%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |