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Omics · study · 2026

Transcriptome profiling of WERI-Rb1 retinoblastoma cells to elucidate ELF2-driven mechanisms of topotecan resistance

Listed in NCBI GEO

To investigate the role of ELF2 in topotecan resistance, we performed RNA-seq on WERI-Rb1 retinoblastoma cells.

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Control (NTC) and ELF2-knockout (sgELF2) cells were treated with either vehicle or 30 nM topotecan for 96 hours. Differential gene expression analysis revealed transcriptomic changes associated with ELF2 loss and its impact on chemoresistance, providing insights into potential mechanisms and therapeutic targets.

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Expression profiling by high throughput sequencing · Homo sapiens
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Life Sciences
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RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE30661515 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (65%)
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title