Omics · study · 2026
Genetic deletion of Usp22 in KRASG12D-p53-null driven lung cancer [RNA-Seq]
Listed in NCBI GEO
Ubiquitin-specific peptidase 22 (USP22), a deubiquitinase and component of the “Death-By-Cancer” 11-gene signature, is overexpressed in multiple cancers and linked to recurrence, therapy resistance, and poor prognosis.
Description
While its role in tumor immune evasion is emerging, the function of USP22 in KRAS-driven lung cancer and antitumor immunity remains largely unknown. Given that oncogenic KRAS promotes an immunosuppressive tumor microenvironment (TME) and resistance to immunotherapy, this study investigates USP22's role in KRAS-driven lung cancer and its potential impacts on carcinogenesis and anticancer immunity.
For this purpose, Usp22 knockout (Usp22-KO) mouse model was developed in the KRASG12D; p53−/− (KP) background, cancers were induced, and bulk RNA-seq analysis was applied to indentify differentially expressed genes and alterated signaling pathways in USP22-KO-KP (KPU-) lung cancers, compared to KP lung cancers.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306017 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306017 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1308972 ncbi.nlm.nih.gov/bioproject/PRJNA1308972 ↗
project · from NCBI GEO
- PubMed 42707650 pubmed.ncbi.nlm.nih.gov/42707650 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE306017 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |