Supplementary file 1_Longitudinal patterns of regional cerebral blood flow during anti-amyloid therapy in mild cognitive impairment: a pilot ASL MRI case series.docx

Arterial spin labeling (ASL) MRI enables non-invasive quantification of regional cerebral blood flow (rCBF) and may provide insight into perfusion patterns observed over the treatment period.</p>Methods<p>This pilot observational case series included participants with MCI or very early Alzheimer’s disease undergoing anti-amyloid therapy (lecanemab), who underwent longitudinal pseudo-continuous ASL MRI at baseline and predefined follow-up timepoints.

Regional rCBF was quantified across predefined cortical and subcortical regions of interest. A comparison group of amyloid-positive participants with MCI who did not receive anti-amyloid therapy underwent baseline ASL MRI. Vascular and metabolic risk factors, including white matter hyperintensity burden and biochemical parameters, were assessed to characterize potential confounding influences.</p>Results<p>Within the treated group, increased rCBF was observed at early follow-up in several frontal, sensorimotor, and subcortical regions.