Fusion genes and lncRNAs in prostate cancer: a comparison in men of African and European descent

These hybrid genes can generate novel proteins with tumorigenic functions.<br><br>The occurrence of vitamin D deficiency is significantly more common in individuals of African descent compared to European descent. Two factors directly contribute to this observed difference; 1. the lack of a nutritionally rich vitamin D diet and 2. higher skin pigmentation. Individuals with darker skin tones have higher levels of melanin present in their skin, a pigment which absorbs and scatters ultraviolet-B radiation thus making it more difficult for individuals of African descent to produce enough vitamin D. Using systems and network biology approaches, this thesis provides a thorough examination of PC racial differences in the areas of the regulatory role of lncRNAs, fusion genes and the effects of vitamin D supplementation on the lncRNA transcriptome.

This was completed using two distinct high-quality datasets which encompassed varying stages of localised PC between patients of African and European descent.<br><br><i>Thesis is embargoed until 31 July 2027</i>.<br><br>