Development of the twin-screw extrusion platform for the manufacture of a liposomal formulation in a single-step, solvet-free and continuous process

This would be beneficial as current liposomal formulations suffer from a number of drawbacks, namely poor stability of liposomal suspensions and the complex manufacturing process. To overcome these drawbacks, selection and understanding of the necessary formulation components was first obtained.

Thermal screening techniques alongside Flory-Huggins Theory was used to achieve this. Following this, an understanding of the system was gathered using a combination of thermal, microscopic and rheological techniques. It was demonstrated for the first time a proliposomal powder could be produced via TSE and upon reconstitution gave a liposomal suspension.