Omics · study · 2026
Multi-tissue single-cell atlas of murine atherosclerosis
Listed in NCBI GEO
Atherosclerosis is a chronic inflammatory disease in which both the innate and adaptive immune systems play a role.
Description
Our objective was to create a multi-tissue single-cell atlas of atherosclerosis using the hypercholesterolaemic Ldlr-/- Apob100/100 mouse model. We used mice fed with either a chow diet or a 3-month high fat diet to respectively represent an early state and a late state of the disease.
We collected four tissues: epididymal white adipose tissue, perivascular adipose tissue, aorta, and spleen, and dissociated them into suspensions containing either all cells or enriched for CD45+ cells (aorta samples). The data has been created using 10X Genomics 5’ single-cell immuneprofiling technology.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE235nnn/GSE235895 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE235895 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA987995 ncbi.nlm.nih.gov/bioproject/PRJNA987995 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus · Other
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 71% · Disease 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE235895 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |