Excel · study · 2026
Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma [HuCCT-1]
Listed in NCBI GEO
Epigenetic alterations play an increasingly recognized role in carcinogenesis and in the development of resistance to anticancer therapies.
Description
In this study, we examined the expression of epigenetic genes to investigate their interplay in cholangiocarcinoma (CCA). We examined 257 epigenetic genes (EpiGs) in transcriptomic data from HuCCT-1 iCCA cells under hypoxia (1% O₂) for 24 h.
We observed that exposing the HuCCT-1 iCCA cell line to hypoxia increased the expression of key epigenetic regulators. Our results suggest that hypoxia may contribute to the activation of a shared epigenetic program associated with malignant transformation and poor prognosis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE314nnn/GSE314257 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314257 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1390614 ncbi.nlm.nih.gov/bioproject/PRJNA1390614 ↗
project · from NCBI GEO
- PubMed 42326014 pubmed.ncbi.nlm.nih.gov/42326014 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Genetics 73%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE314257 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (73%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |