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Excel · study · 2026

The role of Angiopoietin 1 in acute-on-chronic liver failure

Listed in NCBI GEO

Acute-on-chronic liver failure (ACLF) is an acute liver and multisystem failure in patients with pre-existing liver disease.

Description

A common precipitating factor for ACLF is sepsis. Our recent work shows that sepsis-ACLF is associated with loss of Angiopoietin 1 (ANG-1) and endothelial dysfunction that in turn promotes loss of hepatocyte differentiation and liver failure.

However, the mechanism of angiopoietin-mediated endothelial to hepatocyte crosstalk in ACLF is not fully understood. We aimed to study Angiopoietin 1-induced changes in liver cells using spatial transcritomics.

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Stated by source
Mus musculus · Other
From keywords
Life Sciences
Inferred from text
Disease 75%
Provenance · 1 source records, 8 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE34234315 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:diseaseenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:othersource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title