Excel · study · 2026
Pulmonary ILC2-mediated Serotonergic Circuit in RSV‐evoked Airway Hyperreactivity and Cough hypersensitivity
Listed in NCBI GEO
Respiratory syncytial virus (RSV) infection-induced inflammatory mediators interact with immune cells or vagal sensory neurons (VSNs), leading to airway hyperreactivity (AHR) or cough hypersensitivity, both hallmarks of asthma.
Description
Neuronal modulation of group 2 innate lymphoid cells (ILC2s) plays a pivotal role in asthma development and progression. However, the role of ILC2-derived serotonergic signaling in AHR and cough hypersensitivity remains unexplored.
Here, we found that ILC2 expressed Tph1 and released serotonin through C/EBPβ signaling. Utilizing conditional deletion of Tph1 in ILC2s and adoptive transfer approaches in murine asthmatic models, we revealed the contribution of ILC2-derived serotonin in asthma pathogenesis. Mechanistically, we identified that 5-HT2A/NF-κB signaling promotes ILC2 activation.
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Moreover, we discovered an ILC2-vagal sensory neuron interaction via the serotonin/5-HT3A axis, participating in cough hypersensitivity. Clinically, Tph1 and serotonin expressions are elevated and correlate with type 2 cytokine levels in asthma. Collectively, our findings demonstrate an ILC2-dependent serotonergic circuit that regulates immune responses and neuron activation, contributing to AHR and cough in RSV-induced airway disease.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307059 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307059 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1314189 ncbi.nlm.nih.gov/bioproject/PRJNA1314189 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE307059 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |