Omics · study · 2026
Dysregulated calcium underlies hyposalivation and microbial dysbiosis in Down syndrome
Listed in NCBI GEO
Oral diseases have a lifelong impact on human health and quality of life.
Description
Down syndrome (DS) individuals contend with decreased saliva production and periodontal disease for unknown reasons. We investigated the molecular mechanisms of hyposalivation in a DS mouse model (Dp16 mice) and identified decreased Ca2+ uptake in salivary glands essential for saliva fluid secretion.
Human iPSC from DS individuals also showed decreased Ca2+ uptake. Decreased saliva in Dp16 mice altered the oral and gut microbiome enriched in succinate-associate microbes. Metabolomic analysis confirmed elevated succinate levels, a signaling molecule linked to periodontal disease.
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Because Ca2+ dysregulation and hyposalivation are features of Sjogren’s disease, we addressed if DS individuals might be at greater risk of developing Sjogren’s by treating Dp16 mice with DMXAA. Treated Dp16 mice exhibited signs of Sjogren’s. Using the therapeutic agent pilocarpine prescribed in the management of Sjogren’s we enhanced salivation and decreased inflammation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE331nnn/GSE331212 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331212 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1467504 ncbi.nlm.nih.gov/bioproject/PRJNA1467504 ↗
project · from NCBI GEO
- PubMed 42385715 pubmed.ncbi.nlm.nih.gov/42385715 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE331212 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |