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Data · dataset · 2026

<p>Dose response prediction of the total quantity of cAMP with internalization inhibition and with biased receptor spatial distribution for models 3.1 and 3.2 with 95% profile-based confidence intervals.</p>

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<p>The different values of internalization are obtained by varying the parameters <i>ps</i><sub>2</sub>: <i>ps</i><sub>2</sub> = 1, (dotted line), (dash-dot line), (dashed line), no internalization: <i>ps</i><sub>2</sub> = 0 (solid line).

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The different values for <i>p</i><sub>23</sub> are 0 (dotted line), 0.3 (dash-dot line), 0.7 (dashed line) and 1 (solid line), while the internalization rate remains constant for each model (, and ).

Circles represent the value of <i>EC</i><sub>50</sub>. The remaining parameters used for the prediction correspond to the best estimates obtained during model selection (Table C in <a href="ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014790#pcbi.1014790.s001" target="_blank">S1 Text</a>).</p>

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ZivaHuboai:figshare.com:article/3402671113 d agoJSON v1
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