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Table · study · 2026

Spatial Transcriptomics Unveils Immune Microenvironment Heterogeneity and Response-related Subtypes in NSCLC Treated with Neoadjuvant Chemoimmunotherapy

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We conduct a single-arm phase 2 trial using pembrolizumab plus platinum-doublet chemotherapy to evaluate the efficacy and safety of perioperative immune-chemotherapy in patients with driver mutation-negative potentially resectable NSCLC.

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Further, we perform an exploratory analysis of spatial transcriptomic profiles to characterize the immune microenvironment landscape in primary tumor lesions and paired draining lymph nodes after chemoimmunotherapy, aiming to explore distinct pathological response features and potential mechanism.

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Homo sapiens · Other
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Life Sciences
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Cancer 65% · Genetics 68%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE32981315 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[disease].local:disease:cancerenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (65%)
concepts[field].anzsrc:group:3105enrichment · NCBI GEOtaxonomy-embedding@1.1.0title+keywords+description (68%)
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:othersource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[organism].NCBITaxon:9606source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title