Omics · study · 2026
Reduction of di-methyl histone H3K9 (H3K9me2) in CUX1-deficient cells.
Listed in NCBI GEO
CUX1 represses endogenous retroelements leading to an increased inflammatory signature after CUX1 loss.
Description
CUX1 interacts with the histone H3K9 methyltransferase, EHMT2 (G9a). EHMT2, in turn, represses endogenous retroelements (EREs) via the deposition of H3K9me2.
CUX1-deficient K562 cells exhibited a broad reduction in H3K9me2 deposition, with particularly marked losses at LINEs, SINEs, and LTRs, supporting the model that CUX1 represses ERE expression through EHMT2-mediated H3K9me2 deposition.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298147 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298147 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1268428 ncbi.nlm.nih.gov/bioproject/PRJNA1268428 ↗
project · from NCBI GEO
- PubMed 40920873 pubmed.ncbi.nlm.nih.gov/40920873 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE298147 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |