Omics · study · 2026
Candida albicans hyphae induce lung epithelial cytotoxicity and lung barrier disruption in mice and humans [in vivo]
Listed in NCBI GEO
The relationship between Candida albicans recovery from the lower respiratory tract (LRT) of mechanically-ventilated patients and adverse clinical outcomes remains uncertain.
Description
We utilized mouse models to determine whether C. albicans mediates lung injury. Intratracheal C. albicans potentiated lipopolysaccharide-mediated lung barrier disruption.
Notably, in both wild-type and neutrophil-depleted mice, intratracheal C. albicans alone was sufficient to induce lung injury. In lung epithelial cell culture, C. albicans-induced cytotoxicity and barrier disruption were attenuated with a yeast-locked strain unable to form hyphae. Mice intratracheally inoculated with yeast-locked C. albicans showed reduced barrier disruption compared to isogenic control.
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In mechanically-ventilated humans with LRT Candida, we observed hyphae and elevated biomarkers of lung epithelial injury in LRT biospecimens, as well as worse clinical endpoints of lung injury. Therefore, our study suggests that C. albicans hyphae can directly cause lung epithelial injury and barrier disruption and highlights a critical area for future research.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE286nnn/GSE286208 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE286208 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1208122 ncbi.nlm.nih.gov/bioproject/PRJNA1208122 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE286208 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |