24hr Blood Pressure Profiles and Brain Health

This thesis examined 24-hour BP and brain health in adults without dementia. Findings showed that 24-hour BP, particularly higher average levels and greater fluctuations, were linked to poorer brain health, including poorer cognition, injury to the brain’s white matter, altered blood-brain barrier function, or neuronal damage and neuroinflammation.

Sleep and night-time blood pressure patterns also appeared to interact with brain health. Further research is needed to determine whether targeting these BP patterns could reduce dementia risk.