Research Progress on the Application of cGAS-STING Signaling Pathway in Colorectal Cancer

cGAS-STING signaling pathway is a key signaling molecule of innate immune response in vivo,which can recognize exogenous and endogenous dsDNA abnormalities in cytoplasm and promote the release of immune mediators such as INF-I,thus leading to immune response in the body.Previous studies have showed that the cGAS-STING pathway can participate in the development of autoimmune diseases and the immune defense against pathogenic microorganisms.In cancer biology,the cGAS-STING pathway is also responsible for the innate immune detection of cancer and plays an important role in regulating the spontaneous anti-tumor immune response in vivo.Recent studies have suggested that the disturbance of cGAS-STING signal is an important factor in the occurrence and development of colorectal cancer,which can promote tumor growth and metastasis.cGAS-STING signaling is also related to intestinal immune response,and the use of this signaling pathway helps to provide a new target for colorectal cancer immunotherapy.This review aims to introduce the role of cGAS-STING signaling pathway in the occurrence and development of colorectal cancer and the latest research progress,the application of cGAS-STING signaling pathway modulators and their combined therapy in colorectal cancer,and forecast the future research direction of this signaling pathway in the treatment of colorectal cancer.