Omics · study · 2026
Single-Nucleus Multiome Analysis of Atherosclerotic Arteries from Prdm16os KO and Control Mice
Listed in NCBI GEO
Through comprehensive omics data mining, we identified that the lncRNA PRDM16-DT (mouse ortholog: Prdm16os) is enriched in contractile vascular smooth muscle cells (VSMCs) and downregulated during VSMC phenotypic switching in atherosclerosis.
Description
PRDM16-DT is divergently transcribed from PRDM16 gene within a coronary artery disease (CAD) GWAS locus. Fine-mapping and colocalization analyses revealed that PRDM16-DT is the most likely causal gene underlying this association signal.
Global deletion of Prdm16os accelerates atherosclerosis in mice. To further understand the underlying molecular mechanisms, we performed single-nucleus RNA and chromatin accessibility profiling using the 10x Genomics sginel cell multiome ATAC + RNA platform on atherosclerotic aortas from Prdm16os KO and control mice.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336130 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336130 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1480741 ncbi.nlm.nih.gov/bioproject/PRJNA1480741 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Genome binding/occupancy profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE336130 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |