Omics · study · 2026
Detachment-induced gene expression changes in four lung adenocarcinoma cell lines, H2009, LC-2/ad, H2228, and HCC4006.
Listed in NCBI GEO
The aims of the study was to analyze gene expression changes induced by detachment from culture plate.
Description
Of the genes upregulated in detached state, we focused on MUC21, a membrane-anchored mucin, that was previously shown to exhibit anti-adhesive property. Using MUC21-KO cells, we demonstrated that MUC21 play a critical role in the growth and survival of lung adenocarcinoma cells both in attached and detached state.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319718 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319718 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1424998 ncbi.nlm.nih.gov/bioproject/PRJNA1424998 ↗
project · from NCBI GEO
- PubMed 42312560 pubmed.ncbi.nlm.nih.gov/42312560 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Biochemistry and cell biology 71%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319718 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3101 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |