Text · study · 2026
Identification of the RNA that binds with FAK by high-throughput RIP-seq in MDA-MB-231 cells
Listed in NCBI GEO
FAK is overexpressed and aberrantly activated in various advanced solid tumors and plays a critical role in tumor progression and metastasis.
Description
Here, we identified an FAK-interacting lncRNA FAISL, FAISL (FAK Interacting and Stabilizing LncRNA) was frequently overexpressed in TNBC tissues and abundantly enriched in FAK-interacting lncRNAs. FAISL promotes cell adhesion, cytoskeleton spreading, proliferation and anchor-dependent survival of TNBC cells.
FAISL doesn’t affect FAK mRNA but positively regulates the FAK protein level by blocking Calpain 2-mediated proteolysis, etc.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE268nnn/GSE268194 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE268194 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1115097 ncbi.nlm.nih.gov/bioproject/PRJNA1115097 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE268194 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |