Omics · study · 2026
MiRNA profiling of CD8+ T cells, CD14+ monocytes and neutrophils from patients with multiple sclerosis (MS), type 1 diabetes (T1D) and healthy controls (HCs)
Listed in NCBI GEO
Autoimmune diseases (AIDs) arise from complex immune dysregulations involving multiple immune cell types, cytokines and molecular mediators.
Description
Among these, microRNAs (miRNAs) have recently emerged as key regulators of leukocyte processes and are frequently dysregulated in AIDs. However, their role in disease pathophysiology remains poorly understood.
In this study, we performed a comprehensive analysis of miRNA expression in three immune populations, namely CD14+ monocytes, neutrophils and CD8+ T cells, in multiple sclerosis (MS) and type 1 diabetes (T1D), two prototypical AIDs. Our results reveal distinct patterns of miRNA dysregulation in each cell type, with monocytes from T1D patients showing enhanced M1 polarization and inflammatory vascular damage. On the other hand, CD8+ T cells from MS patients show profound alterations related to Tc17 and CD8+ Treg differentiation, apoptosis regulation and migratory capacity.
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Notably, we identified miRNAs that regulate key transcription factors such as FOXP3, IRF4, and RORC, potentially shaping pathogenic T cell responses. Our results suggest that miRNA networks play a central role in orchestrating disease-specific dysregulation in AIDs. By elucidating these intricate regulatory mechanisms, our study provides a foundation for future therapeutic strategies targeting miRNAs in autoimmunity.
MiRNA microarrays were employed to assess the impact of miRNA dysregulations in CD8+ T cells, CD14+ monocytes, and neutrophils, in two AIDs, namely multiple sclerosis and type 1 diabetes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE289nnn/GSE289530 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE289530 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1223377 ncbi.nlm.nih.gov/bioproject/PRJNA1223377 ↗
project · from NCBI GEO
- PubMed 41948457 pubmed.ncbi.nlm.nih.gov/41948457 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Non-coding RNA profiling by array
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE289530 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:non-coding-rna-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |