Single-cell RNA-sequencing of whole blood from human burn patients

However, our cellular and molecular understanding of how humans heal deep dermal wounds remains limited. Our recent work using different animal models of skin wound healing has identified the acute wound healing immune response as a key determinant of terminal fibrotic outcomes.

Here, our goal is to compare the immune response during human wound healing to datasets we have generated from large animal models that are capable of scarless healing, in order to determine how to most appropriately modify the process in humans to improve outcomes (and mitigate scar).