Omics · study · 2026
Gene expression profile in EpCAM+ epithelial cells from mouse esophagus
Listed in NCBI GEO
Esophageal squamous epithelial homeostasis depends on a tightly controlled balance between basal cell self-renewal and stepwise differentiation along the basal-suprabasal-superficial axis.
Description
Disruption of this balance leads to barrier dysfunction and contributes to diseases such as eosinophilic esophagitis (EoE), which is characterized by basal cell hyperplasia. N6-methyladenosine (m6A), the most abundant internal modification of eukaryotic mRNA, is a key regulator of tissue homeostasis through control of mRNA stability and other post-transcriptional processes.
However, the role of m6A, catalyzed by the METTL3/METTL14 complex, in the esophageal epithelium and contribution to disease pathogenesis remain largely unknown.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338986 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338986 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1496757 ncbi.nlm.nih.gov/bioproject/PRJNA1496757 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE338986 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |