Omics · study · 2026
Restoring Circadian Rhythms in the Paraventricular Nucleus Reverses the Epigenetic Clock of Multi Tissues in Aging Mice. [RRBS]
Listed in NCBI GEO
The decline of behavioral and metabolic rhythms with aging underscores the critical role of circadian regulation in health and longevity.
Description
Restoring circadian rhythms has recently emerged as a promising strategy to combat aging-associated disorders. Epigenome remodeling and gene expression changes during cellular senescence.
These epigenomic changes have been widely recognized as hallmarks of aging. Therefore, we examined the DNA methylation levels in aging mice with 3dA treatment and chemogenetic manipulation in PVN. Our results suggest that enhancing circadian rhythm amplitude in paraventricular nucleus (PVN) neurons by 3’-deoxyadenosine (3dA) and chemogenetics significantly reverses the epigenetic clock of multi tissues in aging mice.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE286nnn/GSE286302 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE286302 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1208582 ncbi.nlm.nih.gov/bioproject/PRJNA1208582 ↗
project · from NCBI GEO
Topics
- Stated by source
- Methylation profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE286302 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |