Omics · study · 2026
Scalable expansion and hepatic zone maturation of hepatic progenitor cells from human pluripotent stem cells
Listed in NCBI GEO
We devised a method for large-scale manufacturing of hepatocytes derived from human pluripotent stem cells by modulating levels of FGF19, TGFβ and NOTCH.
Description
We further employed WNT inhibitor and agonist to enhance differentiation efficiency. These differentiation strategies produce hepatocytes cells with improved in vivo functionality and enable their application in 3D bioprinted liver tissue constructs.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299658 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299658 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1275852 ncbi.nlm.nih.gov/bioproject/PRJNA1275852 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE299658 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |