Particle Size Distribution (PSD) Profiles of Polyols

Particle size and particle distribution are important because they influence powder properties (such as bulk density, flowability, and cohesiveness) and thus influence manufacturability (mixability, and segregation) and mixture and tablet structure.

Thus, particle size and particle size distribution of project-related samples of commercially available polyols (such as sucrose, dextrin, inulin, xylitol, sorbitol, isomalt, mannitol, and oligofructose) were characterized by a particle size analyser (Mastersizer 3000; Malvern Instruments, Malvern, UK). Method. The particle size distribution as well as the D10%, D50%, and D90% were determined by a laser diffraction particle size analyser using an Aero S module for dry dispersions (Mastersizer 3000; Malvern Instruments, Malvern, UK) at the specified settings: feed rate of 60%; hopper gap of 0.7-1.5 mm; and air pressure of 0.8 bar.