Omics · study · 2026
Loss of G9a in myofiber accelerates muscle regeneration
Listed in NCBI GEO
Age-related muscle regenerative capacity decline is related to the disruption of the Injured skeletal muscle regenerates through a network orchestrated by multiple muscle-harbored cell types, however, yet the contribution of the interplay between macrophages and myofibers upon injuryto this process is largely unknown.
Description
Deletion of G9a in myofiber mitigates muscle aging and accelerates muscle regeneration. Mechanistically, by deleting Osteocrin (musclin-encoding) in myofiber-specific G9a knockout background, we found G9a suppresses myofiber-derived musclin to inhibit myogenesis and macrophage phenotype transition during muscle regeneration.Musclin recombination protein accelerated muscle regeneration.
Collectively, we highlight an epigenetic mechanism that links muscle aging to muscle regeneration, G9a serves an epigenetic hallmark of muscle aging and a the crosstalk between myofibers and macrophages , both regulated by G9a, steers a pro-recovery microenvironment after muscle injury, which offers therapeutic potentials for muscle regenerative capacity decline in the aged.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299523 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299523 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1274901 ncbi.nlm.nih.gov/bioproject/PRJNA1274901 ↗
project · from NCBI GEO
- PubMed 42270589 pubmed.ncbi.nlm.nih.gov/42270589 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE299523 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |