Omics · study · 2026
The stability of m6A-marked transcripts is linked to cell identity in planarians [MTC KD]
Listed in NCBI GEO
Using Nanopore dRNA-Seq, we generated a high-confidence atlas of ~72,200 m6A sites (minimal methylation rate of 15% in at least two replicates) across the planarian transcriptome.
Description
We identified planarian m6A sites to be installed in a DRAYW context and to be highly enriched near stop codons. Upon depletion of METTL14 – a core component of the methyltransferase complex – we observed a significant reduction of m6A levels by 73.2%, as well as significant gene expression changes in 1059 genes.
Loss of m6A resulted in up- as well as downregulation of genes, but cell type markers were found to be specifically represented in both gene classes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325806 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325806 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1441993 ncbi.nlm.nih.gov/bioproject/PRJNA1441993 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Bioinformatics and computational biology 72%
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE325806 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3102 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |