Omics · study · 2026
Nanopore and EPIC Array Profiling Unmask an Atypical Non-Midline H3 K27-Altered Glioma: a case report
Listed in NCBI GEO
We report a rare adult case of H3K27-altered diffuse glioma arising in an atypical non-midline location, highlighting the diagnostic challenges posed by its radiological and histopathological resemblance to glioblastoma.
Description
The study demonstrates the clinical utility of integrated histopathological, methylation-based, and genomic analyses, including rapid Nanopore methylation profiling, for accurate tumor classification and precision neuro-oncology.
These findings are of direct relevance to neuropathologists, molecular pathologists, neurooncologists, and translational neuroscience researchers.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338747 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338747 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1495515 ncbi.nlm.nih.gov/bioproject/PRJNA1495515 ↗
project · from NCBI GEO
- PubMed 42656225 pubmed.ncbi.nlm.nih.gov/42656225 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by genome tiling array
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65% · DNA methylation profiling 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE338747 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-genome-tiling-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].local:method:dna-methylation-profiling | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |