Accessible chromatin profiling of NK cells and Classical Monocytes from maternally HIV exposed and unexposed children

In order to determine if there is a maternal imprinting on the immune system in children we profiled by ATAC-seq CD56dim NK cells and CD14+ classical monocytes isolated from the PBMC of children that were exposed in utero to HIV but ininfected (HEU) versus children non-infected with HIV and not exposed (HUU).

The HEU group was additionaly stratified by those children who were maternally infected before or during pregnacy. These data begin to define the longtidinal effects of maternal HIV exposure on the innate immune system over the first year of life.