Omics · study · 2026
Targeting YAP1 Attenuates Persistent Oxidative Stress-Driven Tubular Cell Senescence
Listed in NCBI GEO
Persistent oxidative stress induced by hydrogen peroxide (H2O2) upregulates the expression of YAP1 and triggers cellular senescence in HK-2 (human kidney-2) cells.
Description
Conversely, knockdown of YAP1 not only downregulates the Hippo signaling pathway but also suppresses genes involved in extracellular matrix (ECM) reorganization. Furthermore, this YAP1 depletion effectively reduces tubular cell senescence, suggesting that YAP1 acts as a key mediator linking oxidative stress to fibrotic and aging phenotypes in renal tubular cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE333nnn/GSE333763 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE333763 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1467889 ncbi.nlm.nih.gov/bioproject/PRJNA1467889 ↗
project · from NCBI GEO
- PubMed 42381472 pubmed.ncbi.nlm.nih.gov/42381472 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE333763 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |