Omics · study · 2026
Lactiplantibacillus plantarum DS1073 protects the gastric mucosa under infection and alcohol stress
Listed in NCBI GEO
Helicobacter pylori (H. pylori) infection and alcohol consumption are major drivers of gastric injury, highlighting the need for non-antibiotic strategies that prevent colonization and preserve mucosal integrity.
Description
We screened 340 probiotic-derived cell-free supernatants (CFSs) under microaerophilic conditions, assessed anti-adhesion activity using human antral gastric organoids and organoid-derived epithelial monolayers, and evaluated efficacy in mouse models of acute gastric injury induced by ethanol and hydrochloric acid.
Lactiplantibacillus plantarum DS1073 reduced H. pylori viability, inhibited epithelial adhesion, and downregulated key virulence and adhesion genes, including cagA, vacA, ureA, amiE, dupA, hpaA, babA, and ureB. In vivo, both DS1073 CFS and live bacteria decreased gastric colonization and inflammation, improved macroscopic lesion scores, preserved epithelial architecture, restored mucus production, and suppressed expression of acid secretion genes in a mouse model of acute gastric injury.
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Transcriptome profiling of ethanol-injured human gastric epithelial cells revealed attenuation of cytokine–cytokine receptor interactions, reduced mitogen-activated protein kinase signaling, and normalization of calcium signaling pathways. These findings support DS1073 as a promising non-antibiotic strategy to promote and maintain gastric health, particularly by preventing mucosal damage from chronic infection and acute chemical injury.
Clinical evaluation is warranted to assess its preventive and adjunctive potential.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE310nnn/GSE310993 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE310993 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1356689 ncbi.nlm.nih.gov/bioproject/PRJNA1356689 ↗
project · from NCBI GEO
- PubMed 42163327 pubmed.ncbi.nlm.nih.gov/42163327 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE310993 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |