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Omics · study · 2026

Differential transcriptomic responses to naked mRNA vaccine formulations with and without adjuvants in mouse skin and draining lymph nodes

Listed in NCBI GEO

We performed RNA-seq analysis comparing transcriptomic profiles of mouse skin injection sites and draining lymph nodes 24 hours after needle-free intradermal jet-injection of naked spike mRNA vaccines (without lipid nanoparticles) with or without adjuvants (aluminum phosphate and CpG).

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The adjuvanted formulation induced stronger Type I interferon signatures and upregulation of interferon-stimulated genes.

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Expression profiling by high throughput sequencing · Mus musculus
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Life Sciences
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RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE31415315 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (65%)
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title