Data · dataset · 2018
Psammaplysin Derivatives from The Balinese Marine Sponge Aplysinella strongylata
Listed in RIN Data Repository
<p> Twenty-one new psammaplysin derivatives (4−24) exhibiting a variety of side chains, as well as six previously known psammaplysins, were identified from the Indonesian marine sponge Aplysinella strongylata.
Description
The double bond on the side chain of the fatty acid-containing psammaplysins was located by GC-MS analysis of the fatty acid methyl esters and their pyrrolidide derivatives. HPLC and Mosher ester studies confirmed that the isolated metabolites possessing a 19-OH substituent were mixtures of diastereomers.
Selected compounds (4, 5, 7, 8, 12, 18, and 22) were screened for in vitro activity against chloroquine-sensitive (3D7) P. falciparum malaria parasites. Of the new psammaplysins, 19-hydroxypsammaplysin E (4) showed the best antimalarial activity, with an IC50 value of 6.4 μM. </p> <p> Journal of Natural Products, Vol. 75. Hal. 2132-2143 </p>
Links
Where it is published
- RIN Data Repository record hdl.handle.net/20.500.12690/RIN/13CRSC ↗
landing page · from rin brin go id
Catalogue records · 1
- OAI-PMH record data.brin.go.id/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=hdl%3A20.5… ↗
metadata API · from rin brin go id
Topics
- From keywords
- Earth & Environmental Science · Life Sciences · Medicine & Health
Provenance · 1 source records, 6 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| RIN Data Repository | hdl:20.500.12690/RIN/13CRSC | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].local:field:earth-environmental | mapping · rin brin go id | connector:rin_brin_go_id@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · rin brin go id | connector:rin_brin_go_id@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · rin brin go id | connector:rin_brin_go_id@1.0.0 | |
| description | source · rin brin go id | connector:rin_brin_go_id@1.0.0 | /metadata/dc/description |
| publication_date | source · rin brin go id | connector:rin_brin_go_id@1.0.0 | |
| title | source · rin brin go id | connector:rin_brin_go_id@1.0.0 | /metadata/dc/title |