Genetic Instrumental Variables for 211 Gut Microbiota Taxa, 102 Plasma Metabolites, and 3 Parkinson's Disease Phenotypes: SNP Summary Statistics from European Ancestry GWAS

Genomic coordinates were lifted over from GRCh37 to GRCh38.102 Plasma Metabolites: Genetic instruments were derived from a metabolome-wide association study of 8,299 individuals.3 Parkinson's Disease Phenotypes: GWAS summary statistics for PD and related phenotypes were obtained from the UK Biobank and the GWAS Catalogue (sample sizes up to 490,640). All data are from European-ancestry populations to minimize population stratification.Instrumental Variable Selection:Genetic instruments were selected with stringent criteria:Significance Thresholds: SNPs for microbiota (p < 1×10⁻⁵), metabolites (p < 5×10⁻⁶), and PD phenotypes (p < 5×10⁻⁸).This curated dataset provides a robust foundation for causal inference analysis in the gut microbiome-metabolite-PD axis.